Prostaglandins and Related Factors

Biosynthesis of prostaglandins from arachidonic acid in guinea pig lung. Prostaglandins and related factors. 38.

The prostaglandins constitute a class of physiologically active compounds with a widespread occurrence in animal tissues (see References 2 and 3). Previous studies have led to the determination of their structures (4-S), and more recent investigations have shown that they can be formed enzymatically from the essential fatty acids (7,8). It was thus shown that in homogenates of vesicular glands ...

Isolation and Identification of Prostaglandins from Human Seminal Plasma. 18. Prostaglandins and Related Factors.

A depressor substance which stimulates smooth muscle was discovered by Goldblatt and von Euler in extracts of human seminal plasma and of the vesicular glands of sheep (1,Z). The active principle, called prostaglandin, wm shown to have acidic properties. Investigations on its occurrence and biological effects were carried out by von Euler (2) and more recently by El&son (3). Two biologically ac...

Eicosanoids: Prostaglandins and Related Agents

Factors regulating the biosynthesis of various prostaglandins.

the Karolinska Institute working in collaboration with Professor B. Samuelsson. At that time we were able to develop thin-layer techniques which allowed quantitative measurement of the many different products appearing during prostaglandin biosynthesis. This led to the identification of the unusual pros t ag land in , l l -ke to -PGFl , , f rom reaction mixtures(Granstr8m et a1,1968),and a reco...

Pulmonary biosynthesis and metabolism of prostaglandins and related substances.

On passage through the lung vascular bed, prostaglandins are removed from the circulation by a transport carrier and subsequently inactivated by intracellular enzymes. However, PGI2 is not inactivated by the lung in vivo. Although PGI2 is an excellent substrate for the intracellular enzymes in vitro, PGI2 is not a substrate for the carrier system. Thus, the transport carrier determines which ci...